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GIP is a hormone that may complement the effects of GLP-1 receptor agonism

This is because of a hormone called cortisol which is critical for several bodily functions like regulating metabolism

In SARMOUNT-5 trials, tirzepatide participants lost 20.2% of body weight, while semaglutide users showed a 13.7% reduction in body weight over 72 weeks

Tirezepatide doses are higher, and it works on both the GLP1 and GIP receptors

However, persistent itching lasting days, systemic pruritus, or itching accompanied by hives, swelling, or breathing difficulty warrants immediate communication with your healthcare provider

It works by mimicking GLP-1, the hormone responsible for releasing insulin and satisfying hunger